Hyponatraemia and Mortality in Schizophrenic and Bipolar Patients: Protocol for a Bayesian Causal Inference Study

Zealand University Hospital31,740 enrolled

Overview

This study seeks to investigate if hyponatraemia be a direct contributor to death in schizophrenic and bipolar patients, and gauge the potential role of somatic comorbidity and psychotropic polypharmacy, with emphasis on antipsychotics and antidepressants.

Study Type

OBSERVATIONAL

Enrollment

31,740

Conditions

Hyponatremia SIADH

Interventions

Plasma sodium level (continuous variables)OTHER

Observational study, so the exposures of interest (5-year mean and minimum plasma sodium) are not administered to the patients. Ultimately, our interest is in hyponatraemia.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Source population: * Danish residents * At least one International Classification of Diseases version 10 (ICD-10) F2 or F31 diagnosis from a hospital in Region Zealand and the Capital Region (Denmark) No exclusion criteria.

Outcomes

Primary Outcomes

Mortality

All-cause mortality

Time frame: 1 January 2011 through 1 July 2016

Data from ClinicalTrials.gov

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