The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect the molecular epidemiology of infecting organisms for future studies.
Study Type
OBSERVATIONAL
Enrollment
1,000
Jackson Health System, University of Miami Miller School of Medicine
Miami, Florida, United States
RECRUITINGHenry Ford Hospital and Medical Centers
Detroit, Michigan, United States
All-cause, in-hospital mortality
Death by any cause while patient is in the hospital
Time frame: 30 days or until hospital discharge
Number of participants with microbiological outcome
Eradication defined as a negative follow-up blood culture \> 4 days after index blood culture
Time frame: 7 days after first documented positive blood culture
Number of participants with recurrence of bacteremia
Positive blood culture with the same organism within the following 14 days after the documented eradication of bacteremia
Time frame: 14 days after the documented eradication of bacteremia
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University of Mississippi Medical Center
Jackson, Mississippi, United States
RECRUITINGUniversity of North Carolina
Chapel Hill, North Carolina, United States
RECRUITINGUniversity of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States
RECRUITINGMD Anderson Cancer Center
Houston, Texas, United States
RECRUITINGThe University of Texas Health Science Center at Houston
Houston, Texas, United States
RECRUITINGFred Hutchinson Cancer Research Center
Seattle, Washington, United States
RECRUITINGHospital Sanatorio
Buenos Aires, Argentina
RECRUITINGHospital Padre Hurtado
Santiago, Chile
RECRUITING...and 2 more locations