This study aims to investigate the association between hyperlactatemia and neurological disability, length-of-stay and mortality in patients who undergo tumorcraniotomy. The risk factors that induce lactat accumulation will also be explored.
Hyperlactatemia is a frequent occurrence in brain tumor surgery. The existing studies, however, are all retrospective, reporting varying effects on clinical outcome. One study reported new neurological deficitis, some found an association with extended hospital stay, while others found no association with outcome. It is therefore important to conduct a prospective study of hyperlactatemia in this patientgroup. Participants in this study will follow the standard treatment protocol for tumorcraniotomy, aside from 2-3 additional, perioperative blodgas analyses and 2 standardized measurements of neurological disability.
Study Type
OBSERVATIONAL
Enrollment
450
Bloodgas analysis every hour from start surgery until recovery ward discharge
Bloodgas analysis every hour from start surgery until recovery ward discharge
Department of Neuroanesthesiology, Rigshospitalet
Copenhagen, Denmark
Neurological disability
Modified Rankin Scale (Scoring 0-6, high scores meaning worse outcome)
Time frame: Change from baseline mRS at 30 days after surgery
Length of hospital stay
In days from admission to discharge.
Time frame: 1 year
Mortality
Time frame: After 30 days, 6 months and 5 years
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