PROTECT-ASUC: Covid-19 Pandemic Response Of assessmenT, EndosCopy and Treatment in Acute Severe Ulcerative Colitis

Hull University Teaching Hospitals NHS Trust10 enrolled

Overview

Whether the perceived changes in management of Acute Severe Ulcerative Colitis during the COVID pandemic are widespread, and whether they have any impact on patient outcomes

The study aims to evaluate the process, evaluation and therapy variation in management of ASUC with reference to 2019 British Society of Gastroenterology guidelines and see whether there are any differences between ambulatory and hospital management in ASUC. Also to evaluate the outcomes in ASUC patients managed during the COVID-19 pandemic

Study Type

OBSERVATIONAL

Enrollment

Conditions

Inflammatory Bowel Diseases COVID

Eligibility

Sex: ALLMin age: 16 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 16 -100 inclusive * Acute Severe Ulcerative Colitis based on Modified Truelove and Witts Severity Index managed during the study period Exclusion Criteria: * Patients aged 16 -100 inclusive * Acute Severe Ulcerative Colitis based on Modified Truelove and Witts Severity Index managed during the study period * Admission for elective colectomy * Pouch or stoma

Locations (1)

Gastroenterology, Hull Royal Infirmary, Hull University Teaaching Hospitals NHS Trust

Hull, United Kingdom

Outcomes

Primary Outcomes

Primary outcome measure: The need for in-hospital colectomy or rescue therapy

The need for in-hospital colectomy or rescue therapy

Time frame: 3 months

Secondary Outcomes

2.1: Duration and type/route of steroid use

Duration and type/route of steroid use

Time frame: 3 months

2.2: 30 day colectomy free survival rates

30 day colectomy free survival rates

Time frame: 3 months

2.3: Covid-19 infection rates

Covid-19 infection rates

Time frame: 3 months

2.4: Rate of Rescue therapy use

Rate of Rescue therapy use

Time frame: 3 months

2.5: Duration of hospital stay

Duration of hospital stay

Time frame: 3 months

2.6: Admission severity scoring

Admission severity scoring

Time frame: 3 months

2.7: Readmission rates

Readmission rates

Time frame: 3 months

Data from ClinicalTrials.gov

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