The aims of the study are to to associate anticoagulation (AC) regime with outcome in critically ill patients with Covid-19. This will be done by describe baseline characteristics and comorbidities before hospital admission, level of organ support and dose of AC treatment and associate this with 28 days survival, survival outside ICU, thromboembolic event and bleeding complications.
Study Type
OBSERVATIONAL
Enrollment
166
The patients will be categorised into three groups depending on initial regime of anticoagulants after arrival in the ICU.
South General Hospital
Stockholm, Stockholm County, Sweden
28-days ICU mortality
28-days ICU mortality from admission to the ICU. Discontinue of ICU-care to palliative care counts as death.
Time frame: 28 days from ICU-admission
Incidence of thromboembolic events
Thromboembolic events are defined as pulmonary emboli (PE), deep venous thrombus (DVT), ischemic stroke and other peripheral arterial emboli. PE is defined as PE verified by computer tomography or by findings of acute strain of the right heart on echocardiography combined with a clinical interpretation of the patients deteriorating as a probable PE stated in the medical records. DVT is defined as DVT verified with ultrasound. Ischemic stroke is defined as ischemic stroke verified by computer tomography. Peripheral arterial emboli are defined as peripheral arterial emboli verified by computer tomography.
Time frame: 28 days from ICU-admission
Incidence of bleeding events
The event of bleeding will be defined by WHO modified bleeding scale as 1-4.
Time frame: 28 days from ICU-admission
ICU-free days alive from ICU-admission.
ICU-free days alive during 28 days from ICU-admission. Counts as 0 days if discharged to ward for palliative treatment.
Time frame: 28 days from ICU-admission
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