WGS-guided Tracking and Infection Control Measures of CRKP

Huashan Hospital1,000 enrolled

Overview

The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

SCREENING

Masking

NONE

Enrollment

1,000

Conditions

Klebsiella Pneumoniae Infection

Interventions

screen of CRKP and infection control measureOTHER

For intervention group, we screen admitted patients for carbapenem-resistant Klebsiella pneumoniae and carry out 'Bundle' infection and control measures. When outbreak or tranmission of CRKP was observed, we take whole-genome sequencing to track origin and transmission route to decease CRKP rate.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. The patient was admitted to the ICU of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from September 2019 to September 2021, or transferred from the ICU of another hospital 2. The patient is more than 18 years old and less than 80 years old, regardless of gender. 3. Informed consent of the patient; Exclusion Criteria: 1. Patients participating in other clinical trials at the same time 2. Pregnant 4\. People who will affect the outcome of the study: whose specimens could not be received or not enough for testing

Locations (1)

Infectious department of Huashan Hospital, Fudan University

Shanghai, China

RECRUITING

Outcomes

Primary Outcomes

Evaluate the influence of WGS-based screen and control measures on the CRKP occurrence rate

Time frame: 2 years

Secondary Outcomes

Analysis of transmission pattern and route pre and post WGS-based tracking

Time frame: 2 years

Data from ClinicalTrials.gov

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