Effects of Packed Red Blood Cell Storage Duration on Pediatric Living Donor Liver Transplantation

RenJi Hospital360 enrolled

Overview

The patients assigned to either short-storage leukoreduced RBCs group (stored for ≤ 14 days) or longer-term storage leukoreduced RBCs group(stored for ≥21 days).When the hemoglobin concentration fell below 7.0 g per deciliter, PRBC were given to maintain the hemoglobin concentrations in the range of 7.0 to 10.0/dL. The primary outcome : Death from all causes in1-year after randomization. Secondary outcomes included: Intraoperative blood transfusion, Postoperative blood transfusion, Postoperative inflammatory reaction, Mechanical ventilation time in the intensive care unit, Lengths of stay in the intensive care unit and the hospital were also recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

360

Conditions

Transfusion Related Complication

Interventions

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 36 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Our study included pediatric patients (6 months\< the moon's age \<36 months) who will receive standard living-donor liver transplantation (LDLT) in Renji Hospital. Exclusion Criteria: * The exclu¬sion criteria of the study were a congenital sufferer from heart, lung, kidney, nervous system or blood disease,active Lung infection，a history of liver transplantation，Multivisceral transplantation , refused to participate the study.

Outcomes

Primary Outcomes

Mortality in in1-year after randomization

Death from all causes in1-year after randomization.

Time frame: 1-year after randomization.