Oxytocin's Effects on Face Attentional Processing

University of Electronic Science and Technology of China60 enrolled

Overview

To investigate whether intranasal oxytocin (24IU) treatment has a regulatory effect on attentional processing of emotional faces.

In a placebo-controlled double-blind between-subject design experiment, investigators plan to investigate the effect of oxytocin treatment on attentional processing of emotional faces. Subjects complete questionnaires in Chinese versions before treatment administration, including the Beck Depression Inventory, Autism Spectrum Quotient , Trait Anxiety Inventory, Toronto Alexithymia Scale, Multidimentional Assessment of Interoceptive Awareness. This experiment consists of two tasks including Emotional Face Cue-target Task and Visual Search Task. In the first task, subjects need to make a response to judge the position of target after a cue-target is presented. In the second task, subjects are asked to search the target "U" or inverted "U" placed on the nose of emotional/neutral faces and make an choices based on their oorientation. During these phases, subjects' response accuracy, response time and electrophysiological activity (ERP) are recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy

Interventions

oxytocin treatmentDRUG

intranasal administration of oxytocin (24IU)

placebo treatmentDRUG

intranasal administration of placebo (24IU)

Eligibility

Sex: MALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy subjects without past or current psychiatric or neurological disorders. Exclusion Criteria: * history of head injury * medical or psychiatric illness

Locations (1)

School of life science and technology, University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Outcomes

Primary Outcomes

Response time in reponse to different emotional face targets.

Response time in discriminating which side (left or right) the emotional face target appear.

Time frame: 1 hour

N2pc

N2pc is an enhanced negative event-related potential typically elicited at posterior electrodes (e.g., PO7 and PO8) contralateral to the target presented among distractors between 180 and 300 ms after the onset of stimuli. display.

Time frame: 1 hour

Secondary Outcomes

Response accuracy in response to different emotional face targets.

Response accuracy is caculated by the precentage of correct responses among the total responses in discriminating the position (left or right side) of different face conditions.

Time frame: 1 hour

Data from ClinicalTrials.gov

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