This is an open-label, single-dose, absorption, metabolism, excretion, and mass balance study following a single IV infusion of \[14C\]-VVZ-149 in healthy adult male subjects. Whole blood, plasma, urine, and fecal samples will be analyzed for at least 72 hours following the start of infusion to measure total radioactivity and plasma drug concentrations.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
6
A single IV infusion of radio-labeled VVZ-149
Celerion
Lincoln, Nebraska, United States
Mass balance
Sum of the percent of the total radioactivity recovered in urine and feces relative to the administered radioactivity dose
Time frame: Day 15
Total radioactivity (TRA) concentration equivalents in plasma
Time frame: Day 15
TRA concentration equivalents in urine
Time frame: Day 15
TRA concentration equivalents in feces
Time frame: Day 15
Drug concentrations in plasma
Time frame: Hour 48
Treatment-emergent adverse events
Time frame: Day 15
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