This observational study will follow pediatric patients with eosinophilic esophagitis who are scheduled to begin topical steroid treatment, from the initiation of treatment longitudinally to determine the safety profile of the drug.
Study Type
OBSERVATIONAL
Enrollment
55
Athens Children's Hospital "AGIA SOPHIA"
Athens, Greece
Institute of Gastroenterology, Nutrition and Liver Diseases; Schneider Children's Medical Center of Israel
Petah Tikva, Israel
Department of Woman, Child and General and Specialized Surgery, University of the Campania "Luigi Vanvitelli"
Naples, Italy
Maternal and Child Health Department, Sapienza
Rome, Italy
Adrenal suppression
Rates of pathological adrenocorticotropic hormone (ACTH) tests at 3 and 12 months of topical steroid use
Time frame: 3 months
Adrenal suppression
Rates of pathological adrenocorticotropic hormone (ACTH) tests at 3 and 12 months of topical steroid use
Time frame: 12 months
Growth failure
Rates of decreased Height for age after 12 months of treatment.
Time frame: 12 months
Growth failure
Rates of decreased Height for age after 12 months of treatment.
Time frame: 36 months
Bone mineral density
Decrease in bone mineral density between first and second dual energy x-ray absorptiometry (DEXA)
Time frame: 12 months
Bone mineral density
Decrease in bone mineral density between first and second dual energy x-ray absorptiometry (DEXA)
Time frame: 3 years
Hyperglycemia
Rates of elevated fasting glucose after 3 and 12 months of treatment
Time frame: 3 months
Hyperglycemia
Rates of elevated fasting glucose after 3 and 12 months of treatment
Time frame: 12 months
Elevated Liver Enzymes
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Elevated ALT
Time frame: 3 months
Histological remission 3 months
Histological remission at endoscopy timepoints
Time frame: 3 months
Histological remission 12 months
Histological remission at endoscopy timepoints
Time frame: 12 months
Clinical remission
Clinical remission at endoscopy time points according to PEESS v.2
Time frame: 3 months
Clinical remission
Clinical remission at endoscopy time points according to PEESS v.2
Time frame: 12 months