This is a multicenter prospective study that aims to investigate the clinical impact of SARS-CoV-2 infection in pregnant women, pregnancy outcomes and perinatal transmission.
This is a cohort study of pregnant women confirmed positive for SARS-CoV-2 infection. Data will be collected in Portuguese maternities that agreed to collaborate in this study. Pregnant women are tested during hospital admission by using nasopharyngeal/oral swabs for SARS-CoV-2 RT PCR as part of a universal testing policy. Maternal demographic data (age, comorbidities, parity, smoking habits), COVID-19 related data (symptoms, diagnostic tests, therapy used and ICU admission), gestational age at SARS-CoV-2 confirmed infection, pregnancy outcomes (gestational complications, gestational age at birth, mode of delivery) and neonatal outcome (birthweight and Apgar score, RT PCR neonate results) and breastfeeding strategies will be evaluated.
Study Type
OBSERVATIONAL
Enrollment
300
Positive SARS-CoV-2 RT PCR in nasopharyngeal/oral swab tests or presence of IgM in blood samples
Nova Medical School - UNL
Lisbon, Portugal
RECRUITINGSARS-CoV-2 Neonatal Infection
Positive Sars-Cov-2 RT PCR in nasopharyngeal/oral swab tests or presence of IgM in blood samples
Time frame: 7 days
Perinatal mortality
stillbirths and deaths in the first week of life
Time frame: 35 weeks
ICU maternal admission
maternal ICU admission due to COVID-19
Time frame: 35 weeks
5 minute Apgar Score < 7
Newborn 5 minute Apgar Score \< 7
Time frame: 1 day
Preterm labour
Delivery between 24 and 36 weeks
Time frame: 35 weeks
PPROM
Preterm premature rupture of the membranes between 24 and 36 weeks
Time frame: 35 weeks
Miscarriage
spontaneous pregnancy loss before 24 weeks
Time frame: 14 weeks
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