The primary objectives of the proposed project are to assess the long-term effects of prenatal exposure to gestational diabetes or diabetes on the maturation and health of the offspring. In addition, the long-term changes on the health of the affected mothers will be investigated, taking into account the metabolic adjustment during index pregnancy. The expected results will help to establish possible prevention strategies to fight the epidemic of non-communicable diseases for the offspring and the mothers.
Investigation of the long-term outcome of mother-child pairs after diabetic pregnancies and a comparison group regarding metabolic, cardiovascular, neurocognitive and reproductive long-term changes as a function of the course of pregnancy and metabolic control
Study Type
OBSERVATIONAL
Enrollment
100
Basic data collection is carried out by means of a questionnaire that participants can fill in outside the study centre. It contains questions about the current life situation, sleep and activity behaviour.
The physical examination takes place at the study centre and includes the measurement of height, current weight and body fat, as well as the recording of heart and circulation parameters (e.g. blood pressure measurement or determination of vascular health by means of ultrasound). General metabolic and hormonal parameters are analysed by means of a blood sample. In addition, a sugar test for diabetes diagnosis will be carried out.
Universitätsklinikum Jena
Jena, Thuringia, Germany
Metabolic health
effects on metabolic health such as glucose tolerance disorders and diabetes mellitus, obesity and metabolic syndrome (mothers and children)
Time frame: 1 day examination at the study centre
Neurocognitive development
effects on neurocognitive development, mental health and adrenal and autonomic stress reactivity (mothers and children)
Time frame: 1 day examination at the study centre
Cardiovascular and vascular health
effects on cardiovascular and vascular health of blood pressure regulation and endothelial function (mothers and children)
Time frame: 1 day examination at the study centre
Maturation of the gonadal regulation
maturation of gonadal regulation, pubertal development and reproductive health (children)
Time frame: 1 day examination at the study centre
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Psychometric examination is carried out at the study centre with the help of a RIAS (Reynolds Intellectual Assessment Scales and Screening) test.
The adrenergic stress reaction is recorded by a saliva test.