Multimodal Investigation of Intracranial Clot Environment

University Hospital, Montpellier200 enrolled

Overview

Analysis of peri clot blood collected at the acute phase of stroke in order to understand physiopathological mechanisms involved in the cerebrovascular damage

It has been shown that immune cells accumulate around the clot at the acute phase of stroke. Leukocytes and their specific chemokines and cytokines regulation may impact cerebrovascular integrity.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

Acute Ichemic Stroke Brain Ischemia

Interventions

Analysis of the clotOTHER

Blood sampling at the site of intracranial occlusion during Mechanical Thrombectomy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 100 Years

Medical Language ↔ Plain English

Inclusion criteria: 1. Over 18 years of age, 2. Non-dependent for activities of daily living prior to the onset of the MI (Modified Rankin Score \>2) 3. Having an occlusion of a large arterial trunk proven by imaging (angio-MRI or angio-scanner). Exclusion criteria: 1. Patients initially admitted but for whom endovascular treatment will not finally be performed (re-infusion, catheterization failure...) will be excluded from the study. 2. Major patients under guardianship or curatorship or patients deprived of liberty

Locations (1)

University Hospital of Montpellier

Montpellier, France

RECRUITING

Outcomes

Primary Outcomes

Metalloproteinase 9 quantification

Time frame: 60 months

Metalloproteinase 2 quantification

Time frame: 60 months

Secondary Outcomes

Cytokines levels

Proteomic analysis of cytokines IL-1β, TNF-α, IL-6

Time frame: 60 months

Central Contacts

Cyril DARGAZANLI, MD MSc

CONTACT

467337532 c-dargazanli@chu-montpellier.fr

Vincent COSTALAT, MD PhD

CONTACT

467337532 v-costalat@chu-montpellier.fr

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.