HEAD Injury Serum Markers and Multi-modalities for Assessing Response to Trauma

Target Condition Subjects Inclusion Criteria: 1. Age \>=18 years 2. Ability to provide a blood sample; within 96 hours of injury 3. Ability to provide informed consent. Consent may be obtained with assistance of a legally authorized representative (LAR) 4. Must present to the Emergency Department (ED) or Urgent Care (UC) with a blunt head trauma Exclusion Criteria: 1. Glasgow Coma Scale (GCS) score \< 13, as presented in ED at time of screening 2. Need for general anesthesia at the time of presentation in the ED 3. Diagnosed dementia requiring assistance for daily living 4. Any head trauma requiring medical attention from a physician within the last 6 months 5. Received chemotherapy or radiation within the last year 6. History of stroke with disabling outcomes, brain tumor, epilepsy or intracranial surgery/hemorrhage 7. Psychiatric hospitalization in the last 90 days 8. Blood transfusion within the prior 4 weeks 9. Non-working telephone number 10. Current participant in an interventional clinical trial 11. Cannot perform study tasks on an iPad (e.g. not wearing corrective lenses necessary to read, inability to use both hands) 12. Subject considered unsuitable for participation in this clinical trial by PI, treating clinician or research study staff Control Subjects Inclusion: 1. Age \>=18 years 2. Ability to provide a blood sample; (For Trauma Controls (TC's) within 96 hours of injury) 3. Ability to provide informed consent. (For TC's consent may be obtained with assistance of a legally authorized representative (LAR) 4. Presents to the Emergency Department or Urgent Care with at least one injury requiring an X-Ray (TC's only) 5. Healthy and not taking prescription medications (Healthy Controls (HC's) only) Exclusion: 1. Head trauma or symptoms with head trauma at presentation 2. Head trauma requiring medical attention from a physician within the last 6 months 3. Internal organ injury (e.g. liver laceration, pulmonary contusion, spinal cord injury) that requires inpatient hospitalization 4. Need for general anesthesia at the time of presentation in the ED 5. Diagnosed dementia requiring assistance for daily living 6. Received chemotherapy or radiation within the last year 7. History of stroke with disabling outcomes, brain tumor, epilepsy or intracranial surgery/hemorrhage 8. Psychiatric hospitalization in the last 90 days 9. Blood transfusion within the prior 4 weeks 10. Non-working telephone number 11. Current participant in an interventional clinical trial 12. Cannot perform study tasks on an iPad (e.g. not wearing corrective lenses necessary to read, inability to use both hands) 13. Subject considered unsuitable for participation in this clinical trial by PI, treating clinician or research study staff