In the present study, the main hypothesis hypothesizes that the local application of melatonin in the post-extraction socket produces favorable differences in the immediate postoperative period, as anti-inflammatory, analgesic, and early osteogenic regarding the natural healing process of the socket.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Enrollment
38
patients will remove impacted third molar and receive 3 mg melatonin into 2 ml hydroxyethyl cellulose gel 2%
patients will remove impacted third molar and receive 2 ml hydroxyethyl cellulose gel 2%
Cairo University
Cairo, Egypt
Bone density
The bone density within the extraction socket was measured using software of cone beam
Time frame: 6months
Osteoprotegerin (OPG)
Human Osteoprotegerin (OPG) ELISA Kit was used to detect OPG levels.The changes in OPG in the whole group in the predetermined period immediate postoperative , after 4 week,and 6months
Time frame: 4weeks postoperatively
pain sensation
a visual analogue scale (VAS) of 10 units in combination with a graphic rating scale. On the VAS, the left most end represented the absence of pain (score 0) and the right most end indicated the most severe pain (score 10).
Time frame: 7 days postoperative
swelling
a tape measure, from the tragus to the corner of the mouth.
Time frame: 7 days postoperative
trismus
measuring the distance between incisal edges of upper and lower central incisor at maximal mouth
Time frame: 7days postoperative
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