Predictive Value of Doppler RSI for Prediction of AKI in Septic Patients in ICU

Ain Shams University150 enrolled

Overview

Acute kidney injury (AKI) Diagnosis is based on rising creatinine. Intrarenal vasoconstriction occurs earlier and measuring flow resistance in the renal circulation (Renal Resistive Index (RRI)) could become part of vital organ function assessment using Doppler ultrasound. The aim of this study is to predict AKI in septic patients in ICU by measuring RRI on admission by comparing two groups of patients, first group with RRI of normal value (0.6-0.7) and the other group with high RRI more than 0.7 and both with normal renal function on admission.

Patients who have criteria of sepsis, with normal renal function on admission will undergo Renal Doppler Ultrasound examination to measure Renal resistive index. Patients will be divided into 2 groups: 1. Group (A) patients with renal resistive index between 0.6 and 0.7 (normal RRI). 2. Group (B) patients with renal resistive index more than 0.7 (high RRI).

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Acute Kidney Injury Sepsis

Interventions

Renal Doppler UltrasoundDIAGNOSTIC_TEST

Measurement of Renal resistive index

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients who have criteria of sepsis on admission which include two or more of SIRS which include: (Temperature \>38°C or \<36°C, Heart rate \>90/min, Respiratory rate \>20/min or PaCO2 \<32mmHg (4.3kPa) and White blood cell count \>12000/mm3 or \<4000/mm3 or \>10% immature bands.) in addition to suspected or confirmed infection. 2. Patients who have normal renal function on admission. Exclusion Criteria: 1. Currently recovering from an AKI at the time of inclusion and Renal impairment on admission. 2. Patients with obstructive renal failure, renal artery stenosis were excluded from this study. 3. Patients on chemotherapy and/or radiotherapy. 4. Pregnancy.

Locations (1)

Ain Shams University Hospitals

Cairo, Egypt

Outcomes

Primary Outcomes

incidence of AKI

incidence of AKI related to Renal resistive index.

Time frame: 1 day at admission

Secondary Outcomes

APACHE III score

Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 299 worse)

Time frame: 1 day at admission

APACHE IV score

Acute Physiology and Chronic Health Evaluation scores. Score range (0 better - 286 worse)

Time frame: 1 day at admission

SOFA score

Sequential Organ Failure Assessment (SOFA) score. Score Range (0 better - 24 worse)

Time frame: 1 day at admission

Data from ClinicalTrials.gov

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