Use of proton pump inhibitors has been associated with hypomagnesemia. However, various case-control or prospective studies have found conflicting results with regards to proton pump inhibitors use and development of hypomagnesemia. Our aim was to evaluate the likelihood that proton pump inhibitors contributed to severe hypomagnesemia in a retrospective cohort of patients admitted with severe hypomagenesemia. We also aimed to look for risk factors leading to development of hypomagnesemia amongst users of proton pump inhibitors
Study Type
OBSERVATIONAL
Enrollment
211,672
Patients using long term proton pump inhibitor
Changi General Hospital
Singapore, Singapore
Hypomagnesemia due to use with proton pump inhibitor
Number of patients with Hypomagnesemia related to use of proton pump inhibitor using Naranjo score
Time frame: 2013 to 2016
Risk factors for Hypomagnesemia
Odds ratio of developing Hypomagnesemia with risk factors of age, gender, type of drug, dose of drug, chronic renal failure, use of diuretics
Time frame: 2013 to 2016
Hypocalcaemia
Number of patients developing hypocalcemia
Time frame: 2013 to 2016
Hypokalemia
Number of patients developing Hypokalemia
Time frame: 2013 to 2016
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