RT-PCR SARS-CoV-2 at 1 Month of COVID-19 Infection in the Geriatric Population

University Hospital, Strasbourg, France100 enrolled

Overview

Evaluation of the rate of positive RT-PCR SARS-CoV-2 test at 1 month of COVID infection among elderly people. It is unclear how long an individual with COVID-19 will remain "sick" and "contagious". It appears that SARS-CoV-2 can be transmitted before symptoms appear and throughout the course of the disease. They investigators did not find any study on a COVID + geriatric population reassessing carriage at 1 month even though age seems to be a risk factor for prolonged excretion as suggested in the study following study: Xu K, Chen Y, Yuan J, Yi P, Ding C, Wu W, et al. Factors associated with prolonged viral RNA shedding in patients with COVID-19. Clinical Infectious Diseases. 2020 Apr 9; ciaa351

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Covid-19

Eligibility

Sex: ALLMin age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 70years * Patient hospitalized on the geriatric center from March 1, 2020 to August 1, 2020 with a diagnosis of COVID-19 still alive at 1 month. * Patient having agreed to the re-use of their data for the purposes of this research Exclusion Criteria: * Subject who expressed his opposition to participate in the study * Subject under judicial protection

Locations (1)

Service SSR Gériatrique

Strasbourg, France

Outcomes

Primary Outcomes

1. Analysis of the rate of RT-PCR SARS-CoV-2 positive at 1 month of COVID infection

Time frame: at 1 month of COVID infection]

2. Assess quantitative evaluation of a nasopharyngeal swab SARS-CoV-2 RT-PCR test

The objective of this study is to quantitatively assess viral shedding in COVID-19 infected elderly patients who survived infection in order to provide an overview of the evolution of nasopharyngeal swab SARS-CoV-2 real-time reverse transcriptase-polymerase chain reaction (RT-PCR) test results with the Cycle threshold value of the RT-PCR test.. The investigatrors analyze nasopharyngeal RT-PCR at diagnosis. After one month since the date of onset symptoms they reassessed survival patients with nasopharyngeal RT-PCR and repeat the RT-PCR at least every week until final negative conversion occurs.

Time frame: at 1 month after COVID infection

Secondary Outcomes

Assessment of late stool SARS-CoV-2 RT-PCR, serological status and associated factors with death and RT-PCR results 1 month after the date of first symptom onset

* Assessment of late stool SARS-CoV-2 RT-PCR results one month after the date of onset symptom(dso) (% of patients with a positive fecal RT-PCR test after 1 month) * COVID-19 serological status; associated factors with death and RT-PCR results 1 month after the dso: Age (year), gender, Medical history prior to hospilization : Hypertension, diabetes, coronary artery disease, heart failure, atrial fibrillation, chronic respiratory disease, History of medication: ACEI, ARBs Antiplatetet drug, doses of anticoagulant therapy, antibiotic, corticotherapy, statin, Proton pump inhibitor, T°C\>37.8 7 days after the onset of symptoms, weight in kg, height in meter combined to report BMI in kg/m\^2, Charlson score, Use of adjuvant oxygen, Lung CT-Scan results : extent of lesion \<25%/25-50%/50-75%/\>75%, Lymphocytes, platelet, CRP count at the time of diagnosis and 7 days after, GFR at diagnosis ml/min /1.73m2, ABO group, Rhesus antibody, Nasopharyngeal RT PCR initial Cycle Threshold

Time frame: 1 month after the date of first symptom onset