Is Adipose Tissue a Reservoir for SARS-Cov2 Spread in Covid-19 Patients?

Centre Hospitalier Universitaire de Nice5 enrolled

Overview

Resident cells of human adipose tissue express ACE2 and DPP4, receptors for SARS-Cov2. The hypothesis is that the virus may enter and spread in fat depots.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Covid-19 Patients

Interventions

biopsies of subcutaneous adipose tissuePROCEDURE

Two 4mm punch biopsies of subcutaneous abdominal or thight adipose tissue

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Male or female ≥ 18 years old * Patients testing positive for Covid19 * Patients affiliated to social security * Signing of free and informed consent Exclusion Criteria: * Vulnerable persons (- minors, * adults under guardianship or curatorship, * pregnant women, * persons deprived of their liberty, * persons who do not master the French language)

Locations (1)

CHU de Nice

Nice, France

Outcomes

Primary Outcomes

The presence of SARS-CoV2 in adipose tissue of Covid19 patients

RT-qPCR for SARS-Cov-2 from RNAs and by immunodetection

Time frame: Day 0

Secondary Outcomes

The expression of inflammatory cytokines in adipose tissue of Covid19 patients

RT-qPCR for IL6

Time frame: Day 0

The expression of inflammatory cytokines in adipose tissue of Covid19 patients

RT-qPCR for IL1

Time frame: Day 0

The expression of inflammatory cytokines in adipose tissue of Covid19 patients

RT-qPCR for TNFa

Time frame: Day 0

Data from ClinicalTrials.gov

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