The purpose of this follow-up study is to investigate the efficacy and safety of autologous Adipose Tissue derived Mesenchymal stem cells (JOINTSTEM®) in patient with severe Knee Osteoarthritis.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
129
Autologous Adipose Tissue derived MSCs
Keimyung University Dongsan Medical Center
Daegu, South Korea
KyungHee University Gangdong Hospital
Seoul, South Korea
Gangnam Severance Hospital
Seoul, South Korea
The Catholic University of Korea, Seoul ST. Mary's Hospital
Seoul, South Korea
Adverse Events
Incidence of adverse events from baseline to 5 Years
Time frame: 5 Years
Change of Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC) scores from baseline
Pain, stiffness, and physical function of the knee will be measured by the WOMAC score
Time frame: 5 Years
WOMAC 3 subscale score
Pain, stiffness, and physical function of the knee will be measured by the Western Ontario and McMaster Universities (WOMAC)
Time frame: 5 Years
SF-36
The SF(Short Form)-36 Health Survey is a 36-item, patient-reported survey of patient health.
Time frame: 5 Years
Measuring of Kellgren-Lawrence grade
Measuring of Kellgren-Lawrence grade through X-ray
Time frame: 1, 2, 3, 4, 5 Years
Measuring of Femoro-tibial anatomical angle(FTA)
Measuring of FTA through X-ray
Time frame: 1, 2, 3, 4, 5 Years
Measuring of Hip-Knee-Ankle angle(HKA)
Measureing of HKA through X-ray
Time frame: 1, 2, 3, 4, 5 Years
Measuring of Joint Space Width
measuring Joint Space Width through X-ray
Time frame: 1, 2, 3, 4, 5 Years
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MRI scan
The cartilage defect area is measured using MRI
Time frame: 1, 2, 3, 4, 5 Years