Coronary Calcification Study - Intravascular Lithotripsy for Calcified Lesions

Inclusion Criteria: * Age ≥18 years * Informed, written consent by the patient * Ability to comply fully with the study protocol * Negative pregnancy test (and effective contraception) in women with childbearing potential Angiographic inclusion criteria: * Native coronary artery lesion with diameter stenosis ≥50% suitable for PCI * Heavy calcification, defined as calcification within the lesion on both sides of the vessel assessed during angiography * Reference vessel diameter (RVD) ≥2.5 mm with lesion length \<32 mm * TIMI flow 3 of the target vessel at baseline * No visible thrombus at target lesion site Exclusion Criteria: * Cardiogenic shock or haemodynamic instability requiring mechanical circulatory support * Active malignancy or other comorbidities with a life expectancy of 12 months * Limited the possibility of control coronaro angiography (e.g., advanced renal failure) * Known allergy to contrast agents (that cannot be adequately premedicated) or required concomitant dual antiplatelet therapy * Current problems with substance abuse (e.g., alcohol or drugs) * Subject is participating in another investigational drug or device clinical study