Topotecan Episcleral Plaque for Treatment of Retinoblastoma

Inclusion Criteria: 1. Age. Participants must be \<18 years of age. 2. Diagnosis and Treatment. Participants must have: (i) active residual or recurrent intraocular retinoblastoma following completion of first-line therapy (chemotherapy, systemic or intra-arterial, focal therapy or brachytherapy), or (ii) unilateral Group B, C, D or cT1b, cT2 retinoblastoma at diagnosis with no previous treatment. 3. One eye will be the Study Eye. When participants have two eyes with retinoblastoma, the eye with worst disease or best vision potential will be designated the Study Eye. There will only be one eye per child treated in this Phase I study, since treatment of two eyes would double the systemic dose of drug. The Non-study eye will be treated by standard of care, with only focal therapy during the Study Period, if required. 4. Disease status. Study eye must have vision potential and no clinical features suggestive of high risk of extraocular extension. 5. Performance status. Lansky play score ≥ 50 if \<16 years of age; Karnofsky performance scale of ≥ 50 if ≥16 years of age (Appendix I) 6. Organ function: 1. Adequate bone marrow function and platelet count 2. Adequate renal function 3. Adequate liver function 7. Pregnancy prevention. Females of reproductive potential must agree to the use of highly effective contraception during study participation and for an additional 40 days after the end of the Chemoplaque administration 8. Informed consent. All participants and/or their parents or legally authorized representatives must have the ability to understand and the willingness to sign a written informed consent. Assent, where appropriate, will also be obtained. Exclusion Criteria: 1. Disease status. Participants known to have any of the following are excluded: 1. clinical or EUA evidence of extraocular extension 2. known metastatic disease status and intercurrent illness 3. existing clinical and neuroimaging showing suspicion of, or definitive, 2. Allergy. Participants with reported allergy to topotecan, camptothecin or derivatives thereof. 3. Concomitant treatment. Participants may not receive chemotherapy or other focal retinoblastoma therapy or any other investigational agent within 3 weeks of the placement and removal of the Chemoplaque, nor while the Chemoplaque is in situ. 4. Uncontrolled intercurrent illness. Participants with known uncontrolled intercurrent illness that, in the investigator's opinion, would put the participant at undue risk or limit compliance with the study requirements. 5. Febrile illness. Participants with clinically significant febrile illness (as determined by the investigator) within one week prior to initiation of protocol therapy. 6. Pregnancy and lactation. Females of reproductive potential must have a negative serum pregnancy test within 72 hours prior to initiation of protocol therapy. Due to the unknown but potential risk for adverse events (AEs) in nursing infants secondary to treatment of the mother with the study agents, breastfeeding must be discontinued if the mother is treated on study. 7. Compliance. Any condition of diagnosis that could in the opinion of the Principal Investigator or delegate interfere with the participant's ability to comply with the study instruction, might confound the interpretation of the study results, or put the participant at risk.