Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease

Inclusion Criteria: * Admitted to Wellstar Kennestone Hospital * Age 18 years or older * Laboratory-confirmed COVID-19 * At least 1 of the following: 1. Requiring oxygen supplementation at ≤ 4 liters via nasal cannula or increase from baseline 2. Bilateral infiltrates on CXR or CT of chest 3. Age 65 or older 4. Diabetes 5. Hypertension 6. BMI \> 35 7. Chronic lung disease 8. Cardiovascular disease 9. Chronic kidney disease 10. Cancer (hematologic malignancies, lung cancer, and metastatic disease) Exclusion Criteria: * Unable to provide informed consent * Unable to take oral medication * Severe/critical COVID-19 disease at presentation 1. Intensive care or intermediate care required at admission or within 48 hours 2. Requiring oxygen supplementation via high flow nasal cannula, bipap, or non-rebreather mask at admission or within 48 hours * Likelihood of survival \<48 hours in the opinion of the primary physician or transitioned to comfort measures within 48 hours of admission * Inability to take hydroxychloroquine due to allergy, QTc \> 500 ms (male) or 520 ms (female) prior to initiation of hydroxychloroquine, pre-existing retinopathy, known G6PD deficiency, known porphyria, or significant drug- drug interactions * Pregnant or breastfeeding * Severe liver disease (Child-Pugh Class C)