The Belgian Diabetes in Pregnancy Follow-up Study

Universitaire Ziekenhuizen KU Leuven630 enrolled

Overview

Gestational diabetes (GDM) is a form of diabetes that develops during pregnancy. GDM is associated with increased risks for pregnancy complications such as macrosomia s and preterm delivery. Women with a history of GDM have a high risk to develop a type 2 diabetes (T2DM) within the next ten years after delivery. The children are also at increased risk of developing obesity and T2DM later in life. Studies are needed to find more accurate predictors for the metabolic risk later in life. This will help to individualize the follow-up and to develop tailored prevention strategies in women and offspring with a history of GDM. In this research project we will therefore investigate how the long-term metabolic risk can more accurately be predicted in a follow-up cohort of the 'Belgian Diabetes in Pregnancy study' (BEDIP-N). We will study the relationship between maternal weight, degree of body fat and degree of hyperglycaemia in pregnancy on the long-term metabolic risk of 375 women and offspring pairs 3-7 years after the delivery across different gestational glucose tolerance groups based on the 2013 WHO criteria in pregnancy. In addition, we will study whether a promising new biomarker, glycated CD59, is a good predictor for the long-term metabolic risk.

Study Type

OBSERVATIONAL

Enrollment

630

Conditions

Gestational Diabetes Type2 Diabetes Obesity

Interventions

Eligibility

Sex: ALLMin age: 3 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Mothers who participated in the completed BEDIP-N study and received both the GCT as the OGTT during pregnancy * Offspring born at the time of participation in the BEDIP-N study Exclusion Criteria: * Mothers: * Current pregnancy * Treatment that influences glycaemic status such as high dose corticoids. * History of bariatric surgery * gastro-intestinal surgery changing the absorption of glucose (Billroth II) * A normal study visit will not be possible (incompliance, psychiatric problems…) * Diagnosed with type 1 diabetes or the presence of auto-immune antibodies for type 1 diabetes Offspring: * Treatment that influences glycaemic status such as high dose corticoids. * A normal study visit will not be possible (incompliance, psychiatric problems…) * Diagnosed with type 1 diabetes or the presence of auto-immune antibodies for type 1 diabetes

Locations (5)

OLV-Alast

Aalst, Belgium

UZA

Antwerp, Belgium

OLV-Asse

Asse, Belgium

Imelda Bonheiden

Bonheiden, Belgium

UZ Leuven

Leuven, Belgium

Outcomes

Primary Outcomes

A disorder of glucose metabolism in mothers

T2DM defined by the 75g OGTT and/or HbA1c, or prediabetes defined by the American Diabetes Association (ADA) criteria