Phase 3 Efficacy and Safety Study of VVZ-149 Injections for Postoperative Pain Following Bunionectomy

Inclusion Criteria: * Men and women must be at least 18 years of age. Female subjects must meet additional criteria in relation to childbearing potential. * Subjects must be undergoing a planned first metatarsal bunionectomy with osteotomy and internal fixation (Austin bunionectomy) without collateral procedures. * Subjects must have the ability to provide written informed consent. * Subjects must have the ability to understand study procedures and communicate clearly with the Investigator and staff. Key Exclusion Criteria: * Subjects undergoing emergency or unplanned surgery. * Subjects who had any previous bunionectomy procedure on either foot. * Subjects with pre-existing conditions (other than bunion) causing preoperative pain at the site of surgery. * Female subjects who are pregnant or breastfeeding. * Diagnosis of chronic pain and ongoing or frequent use of pain medications.