This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies. Subjects will then be administered an intravenous (IV) load of glycolate, providing additional blood and urine samples afterwards to measure any increase in oxalate levels.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
4
Participants will consume a controlled low oxalate diet for five days.
Participants will come to the UAB Clinical Research Unit (CRU) and be administered a glycolate load via intravenous (IV) catheter.
Urinary Oxalate Excretion
Urinary oxalate excretion from urine samples will be measured as mg/day
Time frame: Baseline through Day 6
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.