Heterozygous Individuals for AGXT and Kidney Stones

N/AEnrolling By InvitationNCT04430426

University of Alabama at Birmingham4 enrolled

Overview

This study seeks to examine the effects of a heterozygous mutation of the AGXT gene in a stone forming population on endogenous oxalate production. Participants will consume a controlled low-oxalate diet and provide blood and urine samples to measure the amount of oxalate in their bodies.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Kidney Stone Urolithiasis, Calcium Oxalate

Interventions

Controlled DietOTHER

Participants will consume a controlled low oxalate diet for five days.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * at least 18 years of age * history of calcium oxalate stones * heterozygous mutation of the AGXT gene, as evidenced by results from the Invitae Nephrolithiasis Panel * willingness to comply with a controlled diet for five days Exclusion Criteria: * pregnant individuals * individuals who are currently breast feeding

Locations (1)

University of Alabama at Birmingham

Birmingham, Alabama, United States

Outcomes

Primary Outcomes

Urinary Oxalate Excretion

Urinary oxalate excretion from urine samples will be measured as mg/day

Time frame: Baseline through Day 4

Data from ClinicalTrials.gov

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