This study will investigate how maternal emotional state following a controlled stress exposure in pregnancy influences blood glucose and insulin levels after eating a standardized meal, and whether the effects of emotional state on blood glucose and insulin is different after eating a healthy meal (low GI) compared to a less healthy meal (high GI).
Maternal glucose-insulin homeostasis in pregnancy represents one of the most important physiological processes for maternal and child health outcomes. Although maternal diet is a key regulator of this process, its effects vary widely across individuals. Maternal stress could represent a moderator of considerable importance in this regard, yet little is known about the effects of stress on glycemic control in pregnancy and whether the effects of stress may vary as a function of diet quality. This project will investigate the effects of acute psychosocial stress exposure on the postprandial metabolic response to a meal of varying glycemic index (GI) among women with overweight/obesity in mid-pregnancy.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
113
The TSST is a 15 minute standardized lab-based challenge task that involves speech preparation, speech delivery while being evaluated by strangers and video taped, and complex mental arithmetic with critiques if errors are made.
Participants will have a relaxed 15 minute conversation with a familiar research team member.
University of California, Irvine
Irvine, California, United States
UCI Medical Center, University of California, Irvine
Orange, California, United States
Postprandial Glycemic Response With Stress Exposure
Glycemic response (area-under-the-curve of glucose) to the assigned meal type during the visit with the psychosocial stress task (TSST)
Time frame: 2 weeks
Postprandial Glycemic Response Without Stress Exposure
Glycemic response (glucose area-under-the-curve) to the assigned meal type during the visit with the non-stress control condition
Time frame: 2 weeks
Postprandial Insulin Response With Stress Exposure
Insulin response (area-under-the-curve) to the assigned meal type during the visit with the standardized stress task
Time frame: 2 weeks
Postprandial Insulin Response Without Stress Exposure
Insulin response (area-under-the-curve) to the assigned meal type during the visit with the non-stress control condition
Time frame: 2 weeks
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