KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.
The purpose of KORN is to investigate the effects of wholegrain oat and rye intake on cardiometabolic health in slightly overweight 8-13-year-old children. Moreover, KORN aims to investigate effects on body weight and body composition, inflammatory markers, gastrointestinal wellbeing and cognitive function and explore the potential underlying mechanisms through assessment of changes in the children's gut microbiota as well as potential genotype-dependent and sex-specific effects. The study has a randomized controlled cross-over design. In two 8-week dietary periods the children will receive grain products (cereals, breads, pasta etc) with either high or low content of wholegrain from oat and rye in random order. Measurements and biological sampling will be performed at 0, 8 and 16 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
55
A selection of grainproducts high in wholegrain from oat and rye, including cereals, bread, rolls, and pasta is replacing habitual grain products
A selection of grainproducts low in wholegrain, including cereals, bread, rolls, and pasta is replacing habitual grain products
Department of Nutrition, Exercise and Sports, University of Copenhagen
Frederiksberg, Denmark
Low density lipoprotein cholesterol
by fasting blood sample
Time frame: 16 weeks
Insulin
by fasting blood sample
Time frame: 16 weeks
Height
by stadiometer
Time frame: 16 weeks
Weight
by digital scale
Time frame: 16 weeks
Body Mass Index z-score
by height and weight measurements
Time frame: 16 weeks
Waist circumference
by measuring tape
Time frame: 16 weeks
Fat mass index
by Dual-energy X-ray Absorptiometry
Time frame: 16 weeks
Fat free mass index
by Dual-energy X-ray Absorptiometry
Time frame: 16 weeks
Systolic blood pressure
by digital device
Time frame: 16 weeks
Diastolic blood pressure
by digital device
Time frame: 16 weeks
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Heart rate
by digital device
Time frame: 16 weeks
Glucose
by fasting blood sample
Time frame: 16 weeks
Glycosylated hemoglobin (HbA1c)
by fasting blood sample
Time frame: 16 weeks
Triacylglycerol
by fasting blood sample
Time frame: 16 weeks
High density lipoprotein cholesterol
by fasting blood sample
Time frame: 16 weeks
Total cholesterol
by fasting blood sample
Time frame: 16 weeks
High sensitivity C-reactive protein
by fasting blood sample
Time frame: 16 weeks
Attention
assessed by d2 test of attention
Time frame: 16 weeks
Inhibition
assessed by Stroop color and word test
Time frame: 16 weeks
Processing speed
assessed by d2 test of attention and Stroop color and word test
Time frame: 16 weeks
Working memory
assessed by Kim's game
Time frame: 16 weeks
Socio-emotional skills
assessed by parent reported Strengths and Difficulties Questionnaire
Time frame: 16 weeks
Stool consistency
assessed by the Bristol stool scale
Time frame: 16 weeks
Gastrointestinal wellbeing
assessed by questionnaire
Time frame: 16 weeks
Prevalence of overweight
By the International Obesity Task Force criteria
Time frame: 16 weeks