Brain Hippocampal Volume Relationship With Anxious Symptoms in Major Depressive Patients

Inclusion Criteria: * First-time patients, without prior antidepressant treatment that meet the diagnostic criteria of DSM 5 for major depressive disorder. * Patients who meet the current major depressive disorder criteria in the MINI interview. * Patients who signed the informed consent for the investigation. Exclusion Criteria: * Patients presenting insufficient data in the MINI interview for current major depression. * Patients diagnosed with intellectual development disorder, by clinic. * Patients with diagnosis of the schizophrenic spectrum, bipolar disorder, autism spectrum disorder, post-traumatic stress disorder and obsessive-compulsive disorder by clinic and / or by the MINI interview. * Patients with contraindications for MRI. * Patients with serious or unstable medical problems. * Patients undergoing some legal procedure. * Patients with difficulties in understanding the interview or completing the assessment instruments.