Evaluating Glial Acetate Metabolism as a Biomarker of Hypoglycemic Complications in Diabetic Patients

Inclusion Criteria: * Male or female * Ages 18-40 years * Diagnosed with type 1 diabetes with positive antibodies or dependent on insulin therapy * HbA1c of ≤8.5% * Modified Clarke's Hypoglycemia Questionnaire score of 12-24 * Willing to participate in continuous glucose monitoring (CGM) Exclusion Criteria: * Contraindication to MRI * Consume \>10 alcoholic drinks/week * Current use of CGM * Current use of insulin pump * Current use of any diabetes medication other than insulin, e.g. SGLT1/2 inhibitors. * Current use of steroids, e.g. cortisone, and prednisone. * History of chronic smoking or have quit less than 10 years ago * History of cancer in the past 5 years (individuals with basal cell or squamous cell skin cancer would be allowed) * History of seizures * Significant, cardiac, vascular, pulmonary, gastrointestinal, neurologic, hematologic, rheumatologic, or psychiatric disease * Significant liver disease as defined as more than twice the upper limit of normal for liver enzymes * Significant renal disease as defined as a estimated glomerular filtration rate less than 30 * Pregnant, planning to become pregnant, or breastfeeding * Have been hospitalized or treated in the past 3 months for severe hypoglycemia * Based on the investigative team's clinical judgement, a subject may not be appropriate for participation in the study.