This study aimed to investigate the effect of smoking and non-surgical periodontal treatment on gingival crevicular fluid CyPA and EMMPRIN levels in patients with periodontitis. Twenty-eight patients with periodontitis (14 non-smoker and 14 smoker) and 30 control subjects (15 non-smoker and 15 smoker) were included into the study. Non-surgical periodontal treatment was applied to all periodontitis patients. Periodontal parameters and GCF CyPA and EMMPRIN levels were evaluated during 3 months following non-surgical periodontal treatment. GCF CyPA and EMMPRIN levels were analyzed by ELISA.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
58
Non-surgical periodontal treatment program was as following: First, motivation and oral hygiene instructions were given to all participants with periodontitis. The modified-Bass tooth brushing technique with a given dentifrice and toothbrush twice a day, and dental flossing/ interdental brushing once a day was advised to all patients with periodontitis. Second, scaling using an ultrasonic device and root planning by hand instruments under local anesthesia was performed.
Change in gingival crevicular fluid CypA total amounts
GCF CyPA levels were analyzed by ELISA
Time frame: Baseline, 1 week, 1., 3. months
Change in gingival crevicular fluid EMMPRIN total amounts
GCF EMMPRIN levels were analyzed by ELISA
Time frame: Baseline, 1 week, 1., 3. months
Change in probing depth
Probing depth was measured with Williams periodontal probe.
Time frame: Baseline, 1., 3. months
Change in bleeding on probing
Bleeding on probing was evaluated the presence or absense following bleeding upon probing.
Time frame: Baseline, 1., 3. months
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