NCT04430803 - Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging | Crick | Crick

Hydrogen-rich Water for Molecular and Phenotypic Biomarkers of Aging

N/ACompletedNCT04430803

University of Novi Sad, Faculty of Sport and Physical Education44 enrolled

Overview

This study evaluates the effects of six-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in men and women aged 70 years and over.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

44

Conditions

Interventions

Hydrogen-rich waterDIETARY_SUPPLEMENT

A tablet that produces hydrogen dissolved in a glass of water

Control WaterOTHER

A glass of tap water

Eligibility

Sex: ALLMin age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 70 years * Free of acute disorders Exclusion Criteria: * History of dietary supplement use during the past 4 weeks

Locations (1)

FSPE Applied Bioenergetics Lab

Novi Sad, Vojvodina, Serbia

Outcomes

Primary Outcomes

Change in TeloTAGGG Telomerase PCR activity in serum

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Secondary Outcomes

Change in DNA methylation

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in blood concentration of advanced glycation end product

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in lipid peroxidation

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in serum FGF21

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in serum TET2

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in ADAS-Cog score (0-70 scale, higher scores indicating greater cognitive impairment)

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in facial wrinkling (0-100 scale; higher scores mean worse outcome)

Baseline vs. 6 months

Time frame: Baseline vs. 6 months post-intervention

Change in maximal oxygen uptake estimated by step-in-place test

Data from ClinicalTrials.gov

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