Primary Progressive Aphasia (PPA) is a neurodegenerative disease in which language function is gradually and progressively impaired. Patients will eventually be disabled in communication and have cognition deficits, which put a heavy burden not only on their families but also on the whole society. However, no effective treatment for PPA has been explored so far. The current clinical randomized trial is to study the safety and efficacy of repetitive Transcranial Magnetic Stimulation (rTMS) for the treatment of PPA. Also, multi-modality of neuroimaging techniques, such as functional MRI and PET will be used to investigate brain network changing in this procedure.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
40
The device is made in London,UK
Peking Union Medical College Hospital
Beijing, Beijing Municipality, China
Boston naming test evaluation
Assessment of the language production. Scores range from 0 to 30. Higher scores means better outcome.
Time frame: 1 day before the treatment
Boston naming test evaluation
Assessment of the language production. Scores range from 0 to 30. Higher scores means better outcome.
Time frame: 1 month, 3 months and 6 months after the treatment
Western Aphasia Battery (WAB) Speech fluency
Assessment of the language production. Scores range from 0 to 20. Higher scores means better outcome.
Time frame: 1 day before the treatment
Western Aphasia Battery (WAB) Speech fluency
Assessment of the language production. Scores range from 0 to 20. Higher scores means better outcome.
Time frame: 1 month, 3 months and 6 months after the treatment
Western Aphasia Battery (WAB) Repetition
Assessment of the repetition ability. Scores range from 0 to 100. Higher scores means better outcome.
Time frame: 1 day before the treatment
Western Aphasia Battery (WAB) Repetition
Assessment of the repetition ability. Scores range from 0 to 100. Higher scores means better outcome.
Time frame: 1 month, 3 months and 6 months after the treatment
Western Aphasia Battery (WAB) Word recognition
Assessment of the reading. Scores range from 0 to 60. Higher scores means better outcome.
Time frame: 1 day before the treatment
Western Aphasia Battery (WAB) Word recognition
Assessment of the reading. Scores range from 0 to 60. Higher scores means better outcome.
Time frame: 1 month, 3 months and 6 months after the treatment
Syntax comprehension part of Bilingual aphasia test (Standard Modern Chinese Version)
Assessment of the grammar ability. Scores range from 0 to 50. Higher scores means better outcome.
Time frame: 1 day before the treatment
Syntax comprehension part of Bilingual aphasia test (Standard Modern Chinese Version)
Assessment of the grammar ability. Scores range from 0 to 50. Higher scores means better outcome.
Time frame: 1 month, 3 months and 6 months after the treatment
functional connectivity map (FC map)
Functional Connectivity was examined using a seed-based voxel-wise correlation approach. The language related brain areas, such as Broca Area and Wernicke Area, were defined as the regions of interest (ROI). Pearson's correlation analysis between the time course of the ROI and that of every voxel in the whole brain was computed for a map of correlation coefficients, which were Fisher's z-transformed and called as z-FC maps. This outcome measurement, the z-FC map, is not numeric data. Z-FC map is a radiographic imaging measurement.
Time frame: 1 day before the treatment
functional connectivity map (FC map)
Functional Connectivity was examined using a seed-based voxel-wise correlation approach. The language related brain areas, such as Broca Area and Wernicke Area, were defined as the regions of interest (ROI). Pearson's correlation analysis between the time course of the ROI and that of every voxel in the whole brain was computed for a map of correlation coefficients, which were Fisher's z-transformed and called as z-FC maps. This outcome measurement, the z-FC map, is not numeric data. Z-FC map is a radiographic imaging measurement.
Time frame: 1 month, 3 months and 6 months after the treatment
Standardized Uptake Value (SUV)
PET parameter to evaluate brain metabolism
Time frame: 1 day before the treatment
Standardized Uptake Value (SUV)
PET parameter to evaluate brain metabolism
Time frame: 1 month, 3 months and 6 months after the treatment
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