Evaluation of Desensitization Therapy and Re-treatment of Eye Movement Information [EMDR] in Patients With Post-traumatic Stress Disorder [PTSD]

Centre hospitalier de Ville-Evrard, France48 enrolled

Overview

This research aims to confirm that the therapeutic effect of EMDR is associated with changes in the interaction between cognitive function and emotional stimuli in PTSD patients compared to a controlled therapy in a randomized, single-blind study.On the other hand, this study aims to observe neuronal and cognitive correlates related to EMDR therapy compared to a control therapy. This investigation would improve the understanding of the mechanisms of action of the EMDR, still unknown to date.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Post-traumatic Stress Disorder

Interventions

Eye Movement Desensitization Reprocessing therapy

The Eye Movement Desensitization Reprocessing therapy uses bi-alternating (right-left) sensory stimulation through eye movements. The patient follows the therapist's fingers from right to left in front of his eyes and also by auditory stimuli. The patient wears a helmet that alternately makes him hear a sound to the right, then to the left or touch the patient holds in his hands buzzers that alternately vibrate from right to left, or alternatively the therapist taps the patient's knees or the back of his hands.

Trauma-Centred Cognitive and Behavioural TherapyBEHAVIORAL

A CBT is a short, scientifically validated therapy that focuses on the interactions between thoughts, emotions and behaviours. These therapies focus on the current problems of the person, while taking into account their historical causes. They help gradually overcome disabling symptoms and aim to strengthen adaptive behaviours. A CBT relies on different techniques that help the patient to identify the mechanisms at the origin of his difficulties, to experiment with new behaviors and thus to gradually come out of vicious circles that perpetuate and aggravate the psychic suffering.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient diagnosed with PTSD according to DSM 5 criteria (APA 2013) related to a single traumatic event, * Aged 18 to 65 years, * Signed informed consent. * Patient with social security affiliation or State Medical Aid (AME) Exclusion Criteria: * Neurological disorders * No other major psychiatric disorders than PTSD (DSM 5) * Severe and/or unstable somatic pathologies, * Patient not affiliated with social security, * Patient hospitalized under stress in psychiatric care at the decision of the state representative or in psychiatric care at the request of a third party, * Patient under guardianship, * Patient participating in parallel with other biomedical research, * Change of antidepressant during the last three months, * Patient not fluent in French * MR-specific criteria for not inclusion: * women of childbearing age without effective contraception or a positive pregnancy test, * patients carrying pacemakers or electrical or electronic devices, clips or metal prostheses, * subjects with neurological disorders, cerebral abnormalities or suffering from claustrophobia.

Outcomes

Primary Outcomes

Post Traumatic Stress Scale-5 (PCL-5)

The PCL-5 is a self-assessment consisting of 20 items that measures the 20 PTSD symptoms of the DSM-5. The wording of the PCL-5 items reflects both changes in existing symptoms and the addition of new symptoms in the DSM-5. The objectives of PCL-5 are numerous, such as monitoring changes in symptoms during and after treatment, screening individuals with PTSD, making an interim diagnosis of PTSD.

Time frame: Before the therapy begins, at day 0

Post Traumatic Stress Scale-5