This study was the evaluate the efficacy and safety of Spirulina maxima extract on the improvement of Cognitive Function
This study was 12 weeks, randomized, double-blind, placebo-controlled human trial to evaluate. 80 subjects participated in Spirulina maxima extract or placebo group. To evaluate the changes in the evaluation items when Spirulina maxima extract was taken 12 weeks compared with placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
80
once a day for 2 p.o., after breakfast and dinner(1.52 g/day, Spirulina maxima extract for 1.5 g/day) for 12 week
once a day for 2 p.o., after breakfast and dinner(1.52 g/day, Spirulina maxima extract for 0 g/day) for 12 week
Department of Psychiatry, Chonbuk National University Hospital
Jeonju, Jeollabuk-do, South Korea
Changes of Visual learning test
Visual learning test of CNT(Computerized neurocognitive function test) was measured in baseline and 12 week. And changes of result from the test were utilized.
Time frame: 12 weeks
Changes of Visual working memory test
Visual working memory test of WMT(working memory tasks) was measured in baseline and 12 week. And changes of result from the test were utilized.
Time frame: 12 weeks
Changes of Verbal learning test
Verbal learning test of CNT(Computerized neurocognitive function test) was measured in baseline and 12 week. And changes of result from the test were utilized.
Time frame: 12 weeks
MoCA-K; Korean Version of the Montreal Cognitive Assessment
The cognitive function evaluation using the Montreal Cognitive Assessment(MoCA-K) is a total of 8 items, and evaluates cognitive functions such as time / execution power, vocabulary, memory, attention, sentence, abstraction, delayed recall, and orientation. Time / execution power's total score is 5 points, vocabulary's total score is 3 points, attention's total score is 3 points, sentence's total score is 3 points, abstraction's total score is 2 points, delayed recall's total score is 5 points, orientation's total score is 6 points. It takes about 10 minutes to complete, and the total score is 30 points and total score make sum score. A score of 23 points or more is regarded as normal. If you have less than 6 years of education, add 1 point. It takes about 10 minutes to complete, and the score is 30 points. A score of 23 points or more is regarded as normal. If you have less than 6 years of education, add 1 point.
Time frame: 12 weeks
Changes of Auditory continuous performance test
Auditory continuous performance test of CNT(Computerized neurocognitive function test) was measured in baseline and 12 week. And changes of result from the test were utilized.
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Time frame: 12 weeks
BDNF; Brain-derived neurotrophic factor
Brain-derived neurotrophic factor(BDNF)(pg/mL) was measured in baseline and 12 week.
Time frame: 12 weeks
Changes of TAS(Total antioxidant status)
Total antioxidant status(TAS) was measured in baseline and 12 week. And changes of result from the test were utilized.
Time frame: 12 weeks