The Safety and Effectiveness of Latuda® Post-marketing Surveillance in the Treatment of Chinese Schizophrenia Patients

The incidence of extrapyramidal symptom

Extrapyramidal Symptoms (EPS) are drug-induced movement disorders that accur due to antipsychotic blockade of the nigrostriatal dopamine tracts, including acute dystonia, akathisia, antipsychotic-induced parkinsonism, tardive dyskinesia (TD)

Time frame: baseline/ week 2-4/ week 6-8/ week 12

The incidence of akathisia

Akathisia is a side effect of antipsychotic drugs, presenting as restlessness, fidgeting of the legs, rocking, pacing, and the inability to sit or stand still.

Time frame: baseline/ week 2-4/ week 6-8/ week 12

the rate of use of extrapyramidal symptom treatment drugs

extrapyramidal symptom treatment drugs are medications to decrease extrapyramidal side effects

Time frame: baseline/ week 2-4/ week 6-8/ week 12

Changes in body weight at the end of treatment compared with baseline

Weight is measured on a scale

Time frame: baseline/ week 12

The overall Brief Psychiatric Rating Scale (BPRS) score change at the end of the treatment compared with the baseline

Brief Psychiatric Rating Scale (BPRS) is a generic scale developed to measure clinical change in patients with schizophrenia and which can be used as a global measure of psychopathology. Each of the 18 items are designed to represent a discrete symptom area. Items are rated on a 7-point Likert scale, from 1 = "not present" to 7 = "extremely severe", with scores ranging from 18 to 126 (achieved through summing the item scores).