Back Pain - Linking Phenotype to Pain Mechanism and Outcome.

Balgrist University Hospital150 enrolled

Overview

To investigate whether different clinical, psychophysical and neurophysiological phenotypes can be identified among low back pain patients

Low back pain patients will fill in a detailed questionnaire (incl. pain drawing) about their pain. Some of them will undergo a standardized quantitative sensory testing protocol and an fMRI procedure.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Low Back Pain

Interventions

no intervention, observationalOTHER

no intervention, observational

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: -primary complaint: low back pain clinically not attributable to red flags Exclusion Criteria: * any major medical or psychiatric condition that affects pain sensitivity * contraindications to MRI

Locations (1)

Balgrist University Hospital

Zurich, Canton of Zurich, Switzerland

Outcomes

Primary Outcomes

spatial pain extent

spatial pain extent (body map)

Time frame: baseline

measures for central sensitization

temporal summation and conditioned pain modulation

Time frame: baseline

Secondary Outcomes

changes in spatial pain extent

changes in spatial pain extent (bodymap)

Time frame: changes from baseline to 3 months

changes in measures for central sensitization

changes in temporal summation and conditioned pain modulation

Time frame: changes from baseline to 3 months

Data from ClinicalTrials.gov

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