Pathogenic Microorganisms in Adult Severe Pneumonia Patients

Shengjing Hospital300 enrolled

Overview

This study aimed to evaluate pathogenic microorganisms in adult severe pneumonia patients in different cities of Liaoning Province

The pathogenic microorganisms of adult patients with severe pneumonia is detected in this study. Clinical treatment does not involve , so it meets the ethical requirements. The clinical data, laboratory test results and imaging data of adult severe pneumonia patients in different hospitals in different cities are recorded. The pathogenic microorganism is detected by second-generation sequencing of lower respiratory tract sputum or alveolar lavage fluid samples, and the data were sorted out to draw the pathogenic microorganism spectrum of adult severe pneumonia in Liaoning area. It will be used to guide clinical empirical treatment.

Study Type

OBSERVATIONAL

Enrollment

300

Conditions

Pathogenic Microorganism of Serious Pneumonia

Interventions

pathogenic microorganismOTHER

Detection of pathogenic microorganisms in adult severe pneumonia by second generation sequencing

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meet the standard of severe pneumonia： Main standards： Requiring mechanical ventilation or septic shock requiring vasoconstrictor therapy. Secondary standards：(only if 3 items are met) Disturbance of consciousness; respiratory rate ≥ 30 times/min; PaO2/FiO2 ≤ 250, or PaO2 \< 60mmHg; azotemia (BUN ≥ 7.12mmol / L); hypotension requires strong fluid resuscitation; infiltration of multiple lobes; leucopenia (WBC \< 4 × 109 / L); thrombocytopenia (\< 10 × 109 / L); hypothermia (T \< 36 ℃). Exclusion Criteria: * refuse to sign informed consent; inaccurate results due to unqualified sputum or BALF samples

Locations (1)

Shengjing hospital of China Medical University

Shenyang, Liaoning, China

Outcomes

Primary Outcomes

Pathogenic microorganism spectrum of adult severe pneumonia in Liaoning Province

Detection of pathogenic microorganisms in severe pneumonia by second generation sequencing

Time frame: 2020.7-2023.12

Data from ClinicalTrials.gov

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