Safety and Feasibility of Reversible Induction Strategy

RenJi Hospital20 enrolled

Overview

This study would explore the safety and feasibility of a reversible induction strategy for uncertain difficult airway. This reversible induction strategy would include high flow nasal canular oxygenation support, short-term effect anesthetic including Propofol and Remifentanil for sedation and analgesia and Sugammadex would be used for reverse the muscle relaxant.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Patients With Uncertain Difficult Airway Colon Cancer Gastric Cancer Prostatic Cancer

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * \>18 years old,\<65 years old * Signed informed consent * Undergoing selective operation （ time of operation is over two hours） * ASA classification I-II * Mallampati classification 3-4 * suspicious difficult airway, but the anesthetists decide to try to rapid induction Exclusion Criteria: * Patients with several dysfunctions of liver, kidney or heart) * Patients with a full stomach or have other risk factors of reflux aspiration * Any medicine was taken before surgery, which might enhance or mitigate the effects of muscle relaxant * Infection of the mouth or nose * Allergy history of any medicine which would be used in this study * Pregnant and lactating women * Patients with neuromuscular disease

Locations (1)

Ren Ji Hospital Affliated to School of Medicine, Shanghai Jiao Tong University

Shanghai, Shanghai Municipality, China

RECRUITING