Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen

Centre Hospitalier Universitaire Dijon62 enrolled

Overview

SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

COVID-19 Severe Pneumonia Severe Pneumonia Due to Other Pathogene

Interventions

biological assays in particular on the lipid metabolismBIOLOGICAL

bioassays carried out on samples already collected and conserved

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (\>=38 °C) Hypothermia (\< 35°C) AND new radiologic pulmonary infiltrate * At admission or within 48 hours following hospital admission * With 2 qSOFA criteria: MAP =\< 100 mmHg, Respiratory Rate \>= 22, Glasgow score \< 15 OR on mechanical ventilation OR under vasopressor * Age \> 18 * affiliated to social security Exclusion Criteria: * Pregnancy * immunodepression * Pathology known to cause severe lymphopenia * hospitalisation within 3 month before inclusion AND sepsis

Locations (1)

Chu Dijon Bourgogne

Dijon, France

Outcomes

Primary Outcomes

Cholesterol concentration

Time frame: Within 48 hours following hospital admission

Secondary Outcomes

LDL cholesterol / HDL cholesterol/ Lipoprotein size and composition/ Non esterified Fatty acid/ Triglyceridemia/ CETP and PLTP activity/ apolipoprotein canceration/ lipid peroxidation/ Pro and anti inflammatory profile.

Ventilator free days (28 days)

Time frame: Within 48 hours following hospital admission

Data from ClinicalTrials.gov

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