The Westlake Gut Microbiome study is a prospective cohort study. This project aims to characterize the gut microbiome among Chinese populations from different regions of China, and explore the relationships between gut microbiota and human health. Human fecal samples will be collected from the participants and muli-omics detection and analysis will be performed.
In the first phase of the study (also a pilot study), the investigators will create a longitudinal datasets from a students-based cohort in Westlake University. Information about demography, life style, diet, medical history, physical activity will be recorded, clinical examinations such as blood glucose, body composition and electroencephalogram will be examined, and biological samples including blood, saliva, urine and feces, will be collected. In the second phase, the investigators will expand to include eligible participants from at least 10 provinces of China, which are located at different regions. Similar to the procedures in phase 1 stage, information about demography, life style, diet, medical history, physical activity will be recorded, clinical examinations will be performed, and biological samples will be collected.
Study Type
OBSERVATIONAL
Westlake University
Hangzhou, Zhejiang, China
Gut microbiota
Fecal microbiome will be analyzed by 16S rRNA gene sequencing and metagenome sequencing.
Time frame: 36 months
Metabolomics of serum and gut microbiome
Metabolomics of serum and gut microbiome will be analyzed by liquid chromatograph-mass spectrometer (LC/MS)
Time frame: 36 months
Proteomic profiling of serum
Proteomic characterization of serum will be analyzed by liquid chromatograph-mass spectrometer (LC/MS)
Time frame: 36 months
Body composition
Body composition will be analyzed using composition automatic analyzer at the time point of sample collection by compostion automatic analyzer.
Time frame: 36 months
Biochemical examination of blood samples
Blood glucose, blood lipids, serum cytokines will be examined.
Time frame: 36 months
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