Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19

Inclusion Criteria: 1. Men or women ≥18 years of age who are UNM HEALTH SYSTEM health care workers and are asymptomatic for known presenting symptoms of SARS-CoV-2: 2. UNMHS HCWs include: MD/DO, NP, RN, and respiratory therapists working in ED, Pediatric ED, Urgent Care, Pediatric Urgent Care or on Covid-19 units. Study PI's will consider study enrollment of HCWs from other settings, for example certain outpatient clinics or inpatient units. 3. Are not positive for SARS-CoV-2 testing 4. Willing and able to comply with survey completion, scheduled visits, treatment plan, and other study procedures 5. Willing and able to provide informed consent Exclusion Criteria: 1. Known hypersensitivity to HCQ or other 4-aminoquinoline compounds 2. Currently hospitalized 3. Symptomatic with subjective fever, cough, or sore throat 4. Current medications exclude concomitant use of HCQ, for example anti-arrhythmic agents, digoxin, cyclosporin, cimetidine, or tamoxifen. 5. Concomitant use of other anti-malarial treatment or chemoprophylaxis 6. History of retinopathy of any etiology 7. Psoriasis 8. Porphyria 9. Known bone marrow disorders with significant neutropenia (polymorphonuclear leukocytes \<1500) or thrombocytopenia (\<100K) 10. Known liver disease 11. Known long QT syndrome 12. Use of any investigational or non-registered drug or vaccine within 30 days preceding the first dose of the study drugs or planned use during the study period. There may be some exceptions to requiring a 30-day washout that will be evaluated by the Co-Investigators on a case by case basis.