Safety and Efficacy of HST 001 in Male Pattern Hair Loss

Inclusion Criteria 1. Must be 25 to 55 years of age inclusive, at the time of signing the informed consent 2. Should be in good general health with a healthy scalp with no cutaneous disorder determined by medical history or physical examination 3. Are classified as III Vertex (3 Vertex), IV (4) and V (5) under the N H Classification for male pattern hair loss (MPHL). Subjects should have some thinning in both the vertex and temporal regions of the scalp 4. Willing to maintain the same hair-style during the study period. No razor shaving of head (bald) prior to study start and throughout the study period 5. Must be Male. 6. Willing to have two dot tattoos of the scalp 7. Willing to have an approximately 1.0 cm2 area of hairs clipped in the vertex region and 0.5 cm2 in one temporal recession area at each visit where macrophotography is conducted 8. Willing to comply with scheduled 7 visits in 26 weeks (or screening in + 6 = 7 visits) 9. Willing to continue normal hair care shampoo throughout the course of the study 10. Willing to maintain the same hair care routine and forgo the use of new scalp products, throughout the study 11. Willing to undergo routine venipuncture for safety laboratory testing as well as a blood spot test for Vitamin D level analysis 12. Capable of giving informed consent 13. Fluent and literate in English 14. Able to follow instructions and likely to complete all study visits as assessed by investigator and staff Exclusion Criteria 1. History of keloid formation or significant hyperpigmentation 2. History of other forms of hair loss - Alopecia areata, trichotillomania, scarring alopecia etc. 3. History of acute or chronic illness that in the opinion of the investigator might confound the results of the study including some drug medications 4. Active skin diseases (eczema, atopic dermatitis, psoriasis, skin cancer, sun-damaged skin with actinic keratosis on the scalp, etc.) in or around the area to be treated 5. Routine use of prescription anti inflammatory medications, immunosuppressive drugs, or antihistamine medications 6. Use of topical drugs or other cosmetics on the scalp 7. Use of over the counter (OTC) or prescriptive topical hair treatments, including hair transplantation during the last 6 months 8. Currently using a hair system or wig 9. History of hair transplants or scalp reduction surgery 10. History of allergy or intolerance to lidocaine and/or epinephrine 11. Use of hair dye within 3 days of the treatments, otherwise, willing to maintain the same hair color for the study duration 12. Current enrollment in an investigational drug or device study 13. Has tattoos or scars in scalp that would interfere with visual assessment 14. Is an employee of the investigator's site, and employee or representative of Histogen, investor, or a relative with one of the above 15. Has a condition or is in a situation which, in the investigator's opinion, may put the participant at significant risk, may confound the study results, or may interfere significantly with participant's involvement in the study 16. Known allergy to rice 17. Known allergy to bovine products