Hydromorphone has a clear analgesic effect, and has few advantages in respiratory depression and gastrointestinal motility. The study will further explore the continuous pumping-dose of hydromorphone for ICU non-mechanical ventilation patients and monitor its effective plasma concentration as well as evaluates the safety and effectiveness of hydromorphone for ICU non-mechanical ventilation patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
530
Intravenous analgesia using hydromorphone in ICU patients with non-mechanical ventilation(NS 40ML+ hydromorphone 10mg ，IV-Pump)
Intravenous analgesia using fentanyl in ICU patients with non-mechanical ventilation(NS 40ML+ fentanyl 0.5mg, IV-Pump)
Intravenous analgesia using butorphanol in ICU patients with non-mechanical ventilation(NS 40ML+ butorphanol 10mg，IV-Pump)
Southern medical university Nanfang hospital
Guangzhou, China
RECRUITINGsuccessful analgesic proportion
Proportion of patients in each group who reached the target analgesia score range
Time frame: From date of using the intervention drugs until the date of leaving from icu, up to 28 days
Score
analgesia score, such as CPOT or NRS
Time frame: From date of using the intervention drugs until the date of stopping using intervention drugs, up to 28 days
dose of analgesics
total dose of analgesics during the study
Time frame: From date of using the intervention drugs until the date of stopping using intervention drugs, up to 28 days
Adverse event
Adverse event during the study, including hypotension.et
Time frame: From date of using the intervention drugs until the date of discharge or death from any cause, up to 60 days
ICU stay
duration of stay in ICU
Time frame: from the date of entering icu until the date of leaving icu or death from any cause, up to 28 days.
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