Several surrogate biomarkers including natriuretic peptide(NP), and growth differentiation factor-15(GDF-15) and ST2 has prognostic significance in heart failure(HF), and reductions in its value may predict clinical improvement. However, there are limited data regarding the prognostic value of these biomarkers during short-term follow-up after discharge in acute decompensated heart failure. The purpose of this study is to evaluate the prognostic value of short-term follow-up surrogate biomarkers for predicting prognosis of hospitalized patients with acute decompensated heart failure.
Study Type
OBSERVATIONAL
Enrollment
1,500
Yonsei University Wonju College of Medicine
Wŏnju, Gangwondo, South Korea
RECRUITINGThe incidence rate (%) of composite endpoint including cardiovascular mortality or hospital readmission
Cardiovascular mortality: death due to heart failure aggravation, arrhythmia, cerebrovascular events, myocardial infarction. Hospital readmission: any readmission
Time frame: 12 months
The incidence rate (%) of all cause mortality
Any death after enrollment
Time frame: 12 months
The incidence rate (%) of cardiovascular mortality
Death due to heart failure aggravation, arrhythmia, cerebrovascular events, myocardial infarction.
Time frame: 12 months
The incidence rate (%) of hospital readmission
Any readmission after discharge
Time frame: 12 months
The incidence rate (%) of hospital readmission due to heart failure aggravation
Readmission due to heart failure aggravation after discharge
Time frame: 12 months
The incidence rate (%) of cerebrovascular events
Stroke or intracranial hemorrhage
Time frame: 12 months
The incidence rate (%) of acute coronary syndrome
Unstable angina or myocardial infarction
Time frame: 12 months
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