Glucocorticoids in COVID-19 (CORTIVID)

Inclusion Criteria: * Age ≥18 years old. * Diagnosis of SARS-CoV-2 pneumonia confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) on nasopharyngeal swab or sputum according to the recommendations of the Spanish Ministry of Health. * Length of symptoms consistent with COVID-19 ≥7 days. * Hospital admission. * At least one of the following: CRP \>60 mg/L, IL-6 \>40 pg/mL, ferritin \>1000 μg/L. * Acceptation of informed consent Exclusion Criteria: * Allergy or contraindication to any of the drugs under study. * SpO2 \<90% (in air ambient) or PaO2 \<60 mmHg (in ambient air) or PaO2/FiO2 \<300 mmHg. * Ongoing treatment with glucocorticoids, immunosuppressive, or biologic drugs with another indication. * Decompensated diabetes mellitus. * Uncontrolled hypertension. * Psychotic or manic disorder. * Active cancer. * Pregnancy or lactation. * Clinical or biochemical suspicion (procalcitonin \>0.5 ng/mL) of active infection other than SARS-CoV-2. * Out-of-hospital management patient. * Conservative or palliative management patient. * Participation in another clinical trial. * Any important and uncontrolled medical, psychological, psychiatric, geographic or social problem that contraindicates the patient's participation in the trial or that does not allow adequate follow-up and adherence to the protocol and evaluation of the study results.