Risk Stratification for Venous Thromboembolism in Hospitalized Medical Patients

Venous thromboembolism

Symptomatic, objectively confirmed fatal and non-fatal hospital-acquired venous thromboembolism, including symptomatic distal and proximal deep vein thrombosis and pulmonary embolism during hospitalization

Time frame: During the initial hospitalization, an average of 7 days

All-cause mortality

All-cause mortality (all causes of death will be considered)

Time frame: During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission

Major bleeding

Major bleeding will be defined as fatal bleeding, symptomatic bleeding at critical sites (intracranial, intraspinal, intraocular, retroperitoneal, intraarticular, pericardial, or intramuscular with compartment syndrome), or bleeding with a reduction of hemoglobin of at least 20 g/L or bleeding leading to transfusion of 2 or more units of packed red blood cells according to the definition of the International Society on Thrombosis and Haemostasis

Time frame: During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission

Clinically relevant non-major bleeding

Clinically relevant non-major bleeding, defined as overt bleeding that does not meet criteria for major bleeding but is associated with a medical intervention, unscheduled physician contact (visit or telephone call), or pain or impairment of activities of daily life

Time frame: During hospitalization (an average of 7 days) and up to 90 days of initial hospital admission

Patient autonomy in the activities of daily living

Patient autonomy in the activities of daily living as assessed by the modified Barthel Index

Time frame: At discharge (an average of 7 days after initial hospital admission) and at 90 days after admission

Length of hospital stay

Length of hospital stay, defined as the time/date of discharge minus time/date of admission at the hospital ward

Time frame: within 90 days of initial hospital admission

Subsequent hospitalizations

Subsequent hospitalization, defined as hospital readmissions

Time frame: Within 90 days of initial hospital admission