The Effects of Exercise on Some Biochemical Parameters in Patients With Rheumatoid Arthritis

Gazi University90 enrolled

Overview

Background: RA may progress with articular and non-articular involvement.Depression prevelance is found to increase for RA patients according to healthy population and to be correlated with pain, decreased quality of life, fatigue and physical disability.BDNF level was found significantly lower in RA patients with depression. Aim of this study is to investigate the variation of BDNF, VEGF, TNF- α, IL-6, IL-1β, irisin and α- Klotho levels following acute exercise. Methods: This study included 45 RA patients and 45 age and sex matched healthy controls. Blood samples from all subjects were taken and centrifuged before and immediately after the exercise intervention.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Rheumatoid Arthritis

Interventions

Aerobic exercise will be performed to all participants for a single session. Maximum heart rate was calculated for each subject (220 - age) and a heart rate monitor (Polar FT 100, China) will be used to follow subjects' heart rate during aerobic exercise.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients who were aged between 18-65 years, * Patients who got diagnosed according to American College of Rheumatology criteria * Patients who were being followed at Firat University Department of Rheumatology Exclusion Criteria: * Patients who had regular exercise habits, malignancy, pregnancy, incorporation, * Patients who took anti-TNF treatment * Patients who had changes of medical treatment in last 3 months * Patients who diagnosed with Fibromyalgia Syndrome and Osteoarthritis for lower extremity * Patients who had cardiac symptoms according to New York Heart Association * Patients who had dysfunction that can prevent physical activity

Outcomes

Primary Outcomes

Irisin

Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.

Time frame: 1 minute

Secondary Outcomes

BDNF, VEGF, TNF- α, IL-6, IL-1β and α- Klotho

Blood samples from all subjects will be taken and centrifuged before and immediately after the exercise intervention. Obtained serums will be stored at the laboratories of Firat University.

Time frame: 1 minute

Central Contacts

Songul B Yentur

CONTACT

0424 237 8282 songulbaglan23@hotmail.com

Süleyman S Koca, Prof. Dr.