The aim of the study is to find biomarkers in the blood and aqueous humor of patients with type 1 choroidal neovascularization and correlate them with the response to anti-VEGF treatment.
Age-related macular degeneration (AMD) is the most frequent cause of blindness in industrialized countries. Multiple molecular pathways have been implicated in the pathogenesis of choroidal neovascularization (CNV). Currently, the treatment relies on neutralization of VEGF (Vascular Endothelial Growth Factor). However some patients have an incomplete response to anti-VEGF treatment. A recent study suggested the implication of the mineralocorticoid receptor pathway in the formation of CNV. The study (of investigators) aim is to evaluate the concentation of metabolites of MR pathway in the blood and aqueous humor of patients with CNV and compared them with patients without CNV in order to increase our understanding of CNV pathogenesis and find potential biomarker of response to anti-VEGF treatment.
Study Type
OBSERVATIONAL
Enrollment
250
Blood analyses and aqueous humor analysis
Ophtalmopole Hôpital Cochin
Paris, France
Hôpital Foch
Suresnes, France
biomarker analysis in blood and aqueous humor of patients with neovascularization and controls
Biomarker concentrations (pg/ml) will be evaluated with ELISA (Enzyme Linked ImmunoSorbent Assay).
Time frame: 24 months
biomarker analysis in blood and aqueous humor of patients with neovascularization and controls
Biomarker concentrations (pg/ml) will be evaluated with Mulitplex Biorad.
Time frame: 24 months
biomarkers and treatment response
Correlation between biomarker level and the response to anti-VEGF treatment
Time frame: 24 months
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