Influence of Positive Margins on Tumour Recurrence and Overall Survival After Gastrectomy for Gastric Cancer

Hospital Universitario Ramon y Cajal267 enrolled

Overview

Incidence of positive surgical margins after curative gastrectomy ranges from 1% to 20%. It has been suggested that positive surgical margins is an adverse prognosis factor, with a higher local recurrence and worse overall survival (OS). However, the management of these patients remains unclear.

Study Type

OBSERVATIONAL

Enrollment

267

Conditions

Stomach Neoplasms

Interventions

ObservationOTHER

The primary aim of this study was to evaluate the influence of positive margins on the tumour's recurrence and OS after gastrectomy for GC. The secondary outcome was to analyse the possible confounding factors that could affect the recurrence and OS after gastrectomy.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * all consecutive patients who underwent an oncological gastrectomy due to gastric cancer, between January 2010 and December 2018 at Ramon y Cajal University Hospital. Exclusion Criteria: * distant disease (including patients with positive cytology), early postoperative mortality (within 30 days after surgery) and follow-up data not available. Resections in patients with palliative intent were also excluded.

Outcomes

Primary Outcomes

evaluate the influence of positive margins on the tumour's recurrence and OS after gastrectomy for GC

Time frame: 8 years

Secondary Outcomes

The secondary outcome was to analyse the possible confounding factors that could affect the recurrence and OS after gastrectomy.

Time frame: 8 years

Data from ClinicalTrials.gov

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